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Macroglial cells produce cytokines, including TGF-, ciliary neurotrophic factor (CNTF), and platelet-derived growth factor (PDGF) (168, 169)

Further, thermolability studies showed that MMACHC protein is strongly stabilised by cobalamin binding, whereas mutant protein was much less stabilised and only minimally or not at all with CNCbl (Ref

On the other hand, the endogenous opioid system is believed to regulate pain intensity and emotional responses

2d) [37]
Dunn GP, Old LJ, Schreiber RD
