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539 Genetic and pharmacological inhibition of TDO and KMO can increase KYNA, but not the level of neurotoxic product 3-HK, thereby improving the symptoms of neurodegeneration
The story of l-glutamine as a proposed treatment for SCA started years ago, remarkably in the 1970s when there was a great interest in finding nontoxic antisickling agents [20]
Mutations in VMAT2 are also associated with schizophrenia

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It was recently shown to also promote the synthesis and expression of the glial glutamate transporter