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The latter is taken up by a membrane-bound phagosome, which further fuses with a lysosome before being destroyed by enzymatic hydrolysis (46)

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Therapeutically, S1P receptor modulators such as fingolimod (FTY720) function by downregulating S1PR1 on lymphocytes, thereby sequestering them in lymph nodes and reducing CNS infiltration (Pournajaf et al., 2022)

Therefore, more studies in humans are needed to support the findings in animals, with a unique methodology, specifying the exact proteins/isoenzymes analyzed, with an adequate number of participants involved, a clear distinction of infertile and fertile men from infertile couples, with defined type of infertility (according to seminogram characteristics, confirmed after two semen analyses), careful control of possible confounding, and elimination of other possible known reasons for male infertility