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Alzheimers disease: a journey from amyloid peptides and oxidative stress, to biomarker technologies and disease prevention strategies-gains from AIBL and DIAN cohort studies

68 Of note, the BNIP3/NIX pathway was specifically up-regulated when mitochondrial oxidative stress was generated in the hypoxic environment to further induce mitophagy

The passive pressure-diameter relationship in middle cerebral arteries that were maximally dilated with Ca 2+ free solution was also similar in S-D rats fed HS diet and LS Diet Protandim (Supplement Figure 2), demonstrating that HS diet and/or Protandim treatment had no effect on the passive mechanical properties of the arteries

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