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Biomarkers of inflammation and repair in kidney disease progression

Non-motor symptoms in Parkinson's disease encompass a variety of functions, such as disturbances in sleep-wake cycle regulation, cognitive dysfunction (such as frontal executive dysfunction, memory retrieval problems, dementia, and hallucinations), mood and affect disorders, autonomic dysfunction (primarily orthostatic hypotension, urogenital dysfunction, constipation, and excessive sweating), sensory symptoms (especially reduced sense of smell), and pain

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They exhibit high activity of drug efflux pumps such as ABCG2, which actively expel chemotherapeutic drugs from the cell, reducing intracellular drug concentrations (55)