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Emerging Infectious Diseases (Book review)

2017;12(4):e0174847

Nose Y, Kim BE, Thiele DJ

It also requires methyl nutrients including riboflavin (vitamin B2), cobalamin (vitamin B12), pyridoxine (vitamin B6) and choline (vitamin B4), as well as methionine and betaine, which act as substrates and cofactors in the methylation process [8].* Even a high dose of L-methylfolate will have little effect on methylation if these other cofactors are not present in adequate amounts.* Optimize Your Liver and Gut A healthy liver and microbiome can help pick up the slack in detoxification

In B-type PACs, the linkage between the successive monomeric units is usually between the C4 position of the upper unit and the C8 or C6 position of the lower unit