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Interestingly, it can be noted that whereas NEM pre-treatment was a common feature in the first clinical studies, more recently this use was pretty abandoned

The weekly 2.4 mg maintenance dose is FDA-approved for chronic weight management and represents the standard clinical approach [3] [4]

Peptide drugs, on the other hand, can be designed to bind tightly with Mcl-1, preventing it from interacting with its natural binding partner in the cell

doi: 10.1055/a-0658-7889 [DOI] [PubMed] [Google Scholar] 11