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Its stability and resistance to degradation in the gastrointestinal tract make it a unique subject for both systemic and oral administration models

The no observed adverse effect level (NOAEL) was determined to be 540 mg/kg, equivalent to 24 times the human clinical dose (448 mg/person/28 days), supporting the safety margin of rotigotine behenate loaded in PLGA microspheres and its potential for advancement into phase I clinical trials for PD 137

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BPC 157 co-administration restated a beneficial effect in the NO-system immobilization (the L-NAME+L-arginine+BPC 157 rats), and BPC 157 overwhelmed the effect of L-arginine as well as the effect of L-NAME and counteracted NO-system immobilization

In the control group, no significant differences were also found, which is obviously due to the narrow age range in the groups included in the study