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Under normal conditions, the bodys oxidation and antioxidant activity are in dynamic equilibrium

Statistical significance was evaluated in pairwise comparisons with control values using a One-way and Two-way ANOVA test after confirmation of normal distributions with GraphPad Prism 8.0 and R (v 4.3.1)

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14 of 31 patients (45%) had AFXa activity below normal (subtherapeutic)

It was revealed that Vit C increases to induce midbrain-derived neural stem cells into dopaminergic neurons by increasing 5-hydroxymethylcytosine and decreasing histone H3 lysine 27 tri-methylation generation in the dopamine phenotype gene promoters, which are catalyzed by ten-eleven-translocation 1 (Tet1) methylcytosine dioxygenase 1 and histone H3K27 demethylase (Jmjd3), respectively