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However, it is important to note that the inadequate efficacy observed could be owing to a suboptimal dose regimen, or inadequate treatment or observation period

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doi: 10.1016/j.mrgentox.2016.09.010 121 HeydarzadehSKiaSK

In a post-hoc single-cell RNA sequencing analysis, data from patients with RMC before and after nivolumab plus ipilimumab treatment indicated that immune checkpoint therapy (ICT) triggered an interferon- response that induced a myeloid mimicry program in tumor cells, regulated by the CEBPB / p300 axis and linked to proliferation and hyperprogression

Micel, L