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Below, linkers employing these various release strategies will be discussed for each cytotoxin class since the few linker-drug motifs that have been successful have repeatedly been used for other antibodies

Zakharia et al., Utilization of redox modulating small molecules that selectively act as pro-oxidants in cancer cells to open a therapeutic window for improving cancer therapy

In vitro studies have suggested that the cytotoxic capacity of NK cells from obese individuals is diminished due to decreased expression of granzymes and perforins, impairing their ability to eliminate damaged cells 48

G., Rosendahl, A

Studies of the adrenal glands of poultry at the cellular level have indicated that cortical tissue is represented by acidophilic cells and medullary tissue by basophilic cells
