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L-carnitine suppresses transient receptor potential vanilloid type 1 activation in human corneal epithelial cells

Snapshot Proponents Effective for L-carnitine deficiency Supports mitochondrial health and energy function Allegedly supports liver and brain health May improve PCOS in women and semen quality and fertility in men Skeptics Many popular uses are not supported by evidence May contribute to heart disease by metabolizing TMAO Can cause nausea or stomach upset Long-term use may cause oxidative stress in the liver and blood Affects thyroid function Health Benefits of Carnitine Effective for: L-Carnitine Deficiency (Genetic) Oral and intravenous L-carnitine is effective for the treatment of primary and secondary L-carnitine deficiency due to inborn errors of metabolism (genetic)

[88] found that pretreatment of mice with intraperitoneal injections of L-carnitine , suppressed both tonic and clonic seizures induced by pentylenetetrazol in a dose-dependent manner

Increasing research on ERS has proven that it plays an important role in the development of various cardiovascular diseases (70)