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Consistent with animal models, several investigations have reported elevated levels of blood endotoxins in adult patients with simple steatosis, hepatitis and NASH [150]

Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells

The model was first fitted to the training concentrations (37.5 and 25 M doxorubicin), and then used to simulate the test concentrations (50, 12.5 and 10 M doxorubicin) as a means of blind validation, showing good accordance between the experimental and in silico outputs for all concentrations of doxorubicin

This pairs with the angiogenic finding: a tissue cannot remodel its extracellular matrix without microvascular supply, and the compound appears to act on both arms of the wound-resolution cascade simultaneously

Functional reconstitution of HBV-specific CD8 T cells by in vitro polyphenol treatment in chronic hepatitis B