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In the altered scenario of cholestasis, the retention of more hydrophobic bile salts, such as the glyco- and tauro-conjugates of deoxycholate, plays a major part in the onset of liver injury, causing hepatotoxicity due to mitochondrial dysfunction and production of ROS, with consequent oxidative damage [181,182]
[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Liu Y., Wu Y., Luo Z., Li M
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Additionally, celastrol demonstrated an inhibitory effect on hearing loss in mice subjected to systemic aminoglycoside treatment
Brain 140 , 16431656 (2017)
