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however, much evidence shows that pathways involving nerves connecting the nasal passages to the brain and spinal cord are essential

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Furthermore, all experiments were carried out under blind protocol and the effect was assessed by examiners who were completely unaware of the given protocol

Thyroid hormone and TR agonists are potent inducers of OPC differentiation 48,49,50 and enhancers of remyelination 51,52,53,54,55 , but their use as remyelination therapeutics has been precluded by peripheral side effects