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Furthermore, elevated UA levels are associated with endothelial dysfunction, vascular injury and remodeling, and increased inflammatory responses [128], and the protective effects of UA can be masked when it exceeds a certain level
Recently, an increasing number of studies have demonstrated the important regulatory role played by epigenetic mechanisms, especially DNA, RNA, and protein methylation, in ferroptosis
2A, B and detailed in Supplementary Data 2
Tkalcevic VI, Cuzic S, Brajsa K, et al
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