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By inhibiting NNMT, 5-amino-1MQ improves glucose clearance from the blood and enables cells to more rapidly use available energy, reducing glycogen and fat deposition [1, 3]
In RHM model, PDH activity was adjusted 2 times respect to the activity determined ( Supplementary Table S1 ) to improve the model prediction of metabolite concentrations and KC flux

Drug Metab Pharmacokinetics 2014;29(5):367-72

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How does combining MOTS-c and 5-Amino-1MQ enhance metabolic outcomes compared to using either compound alone
