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However, another study using the CLP mouse model found that administering choline before and after sepsis initiation reduced serum inflammatory mediators such as TNF- and HMGB1, and improved survival via the 7nAChR-dependent mechanism (250, 251)

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Park DJ, Kang JH, Yim YR, Kim JE, Lee JW, Lee KE, Wen L, Kim TJ, Park YW, Lee SS

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LFs therapeutic effects include mitigating CECs damage and promoting cellular repair, as demonstrated in animal models of DED (Pattamatta et al., 2013

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10.1007/s11897-016-0298-4 118 WachterR.ShahS

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