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In vascular smooth muscle cells, hyperinsulinemia also promotes cell proliferation, contributing to the development of atherosclerosis and vascular remodelling

Nevertheless, in some clinical studies, contradictory findings have been reported

Our molecular modeling and MD simulation analyses of an RNA/cDNA complex containing a VQ-modified base suggest that the VQ moiety stacks with the terminal base of the growing cDNA strand (at the 1 position), thereby occupying the incoming nucleotide binding position (Supplementary Fig

10.1111/nyas.12971 15 Brown-BorgH

For OA, employing local intra-articular administration is expected to significantly reduce systemic exposure and related immune reactions, thus being considered a more realistic clinical translation pathway (Lin et al., 2024