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Analyzing exon 5 in the TP53 gene in relapsed childhood ALL revealed a mutation in 19% of patients (12% in B-lineage and 33% in T-lineage), most of them were identified in the relapse phase

250-252 In addition, assisted reproductive technique-conceived babies have been found to be more likely to experience perinatal problems (eg, low birth weight and preterm birth) compared with those conceived naturally, and some evidence suggests they may be at higher risk of cardiovascular problems later in life
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