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Given that studies have shown that saphenous vein of humans and animals exhibits an active myogenic response and that stretch-induced AT1R and TRPC channels signaling mechanism are responsible for the myogenic response in arteries, it remains, however, to delineate the underlying signaling pathways and the identity of mechanosensors of myogenic response in human superficial veins of the lower extremities

The methyl group acts like an on/off switch for major metabolic processes

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