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Additionally, abrupt discontinuation of gabapentin should be avoided as it may precipitate withdrawal symptoms or seizures

It is believed that the Werner syndrome (WS), which is characterized by severe metabolic dysfunction, dyslipidemia, early atherosclerosis, and insulin resistance diabetes, most closely resembles the aging process (23)

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2023;237 doi: 10.1016/j.bios.2023.115469

On a molecular level, the negative effects of OS may be the result of lipid damage, inhibition of protein synthesis and depletion of ATP, with reproductive consequences including the destruction of oocytes, altered endocrine function, and endometrial damage, all of which have adverse implications for pregnancy implantation and continuation (Kaltsas et al., 2023), estrogen may have beneficial effects in terms of antagonizing the impact of oxidative stress