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Angiotensin II-induced overexpression of sirtuin 1 contributes to enhanced expression of gi proteins and hyperproliferation of vascular smooth muscle cells

This model proposes that mGSH depletion due to its covalent binding to NAPQI acts as a first-hit, which is followed by a burst of mitochondrial ROS production that activates a second hit involving mitogen-activated protein kinases (MAPKs) that in turn amplifies the wave of mitochondrial ROS generation (Lemasters, 1998)

UK guidelines recommend monitoring clinical response and full blood count (typically at around 2 months) to ensure treatment adequacy, rather than routinely rechecking B12 levels after replacement has started

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Li Y, Shen X, Ding H, Zhang Y, Pan D, Su L, Wu Y, Fang Z, Zhou J, Gong Q, Luo K