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Australas J Dermatol

Despite the improvement in response rates with various modulation strategies such as chemotherapy combined with targeted therapy, radiotherapy, and immunotherapy, the prognosis of mCRC is poor, with a 5-year survival rate of 14%, and the primary reason for treatment failure is believed to be the development of resistance to therapies

doi: 10.3389/fcell.2022.860344 Received 22 January 2022 Accepted 28 March 2022 Published 30 June 2022 Volume 10 - 2022 Edited by Haiyang Zhang, Tianjin Medical University, China Reviewed by Yihuang Gu, Nanjing University, China Zhengyu Li, Shanghai University of Traditional Chinese Medicine, China Updates Copyright 2022 Gu, Xia, Li, Zou, Lu, Ren, Zhang and Sun

The overexpression of antioxidant molecules such as GSH and SOD2, or chaperones such as Hsp70 has proved to be a successful experimental approach in brain diseases, including PD