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The crucial cellular event is enhanced tyrosinase activity

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doi: 10.1177/2045894018767393 157 ZhouW.LiuX.van WijnbergenJ
Initially, the animals received a single intraperitoneal injection of one of the following treatments: vehicle control (0.9% normal saline or 10% DMSO), cetirizine (10 mg/kg), Icatibant (1 mg/kg), celecoxib (50 mg/kg B

however, dysregulation of these channels is a critical factor in the transition from acute to chronic pain that is usually observed in fibromyalgia [181,182]
