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As illustrated in Figure 2, pyroptosis is a form of programmed cell death mediated by inflammasomes, in which activation of the NLRP3 inflammasome triggers caspase-1
Participants who made it past week 12 without stopping had an 87% chance of hitting at least 15% total weight loss by week 48
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This special interplay further highlights that the loss of any one system can overwhelm the compensatory capacity of the others, forcing the CNS into a state of redox imbalance, glial activation, and progressive inflammation (Figure 1)
