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In contrast, IRP2 knockdown or treatment with the ferroptosis inhibitor Fer-1 alleviates PC-12 cell damage by downregulating p53 levels and activating the SLC7A11-ALOX12 signaling pathway ( In summary, CDC42, derived from neural stem cell-derived exosomes, as well as TIGAR, FTO, and IRP2, contribute to PD pathology by regulating iron homeostasis, ferroptosis, fatty acid metabolism, the antioxidant system, and angiogenesis

Bayberries color index was determined as CIRG = (180 h)(C + L

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Expected Timeline for Results Initial Improvements: Noticeable skin brightness and clarity may be seen after 4-6 weeks of consistent treatment