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The GHR belongs to the class 1 cytokine receptors which uses STAT as one of its principal secondary messengers, and the subsequent phosphorylation of two STAT5b molecules results in a phospo-STAT5b homodimer which translocate to the cell nucleus, binds to STAT5b recognition sites on the IGF1 gene promoter, and initiates transcription (Figure 3)

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[DOI] [PubMed] [Google Scholar] 5.Hill V.M., OConnor R.M., Sissoko G.B., Irobunda I.S., Leong S., Canman J.C., Stavropoulos N., Shirasu-Hiza M

Vitamin B12 Mechanism of Action in the Nervous System Vitamin B12 influences and regulates the creation and maintenance of the myelin sheaths through four different mechanisms: Required for the formation of lipids and proteins, from which myelin is created Lowers the level of amino acids, which are probably neurotoxic Works like a hormone in the central nervous system and regulates the level of important cytokines and neurotrophic factors Is a crucial antioxidant in the central nervous system and, through different mechanisms, protects the nerves from chronic inflammations, reactive oxygen and nitrogen radicals and toxins (22 24) Vitamin B12 and the Creation of the Myelin Sheaths Both active coenzyme vitamin B12 forms have an influence on the structure of the myelin sheaths

It is worth delving into its pathogenic mechanism and the regulatory mechanisms both physiologically and pathophysiologically (179)