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In 1920, it was reported that antibodies can recognize and bind substances with a specific structure, "antigens" [8]

Neurochem Int (2006) 49(8):7648

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This suggests that therapeutic research focusing on DYRK1A inhibition should, at least in part, also take care of the problem of CBS triplication, at the condition that these inhibitors are specific of DYRK1A and do not inhibit GSK3 as well, as our data suggest that GSK3 activation is needed to reduce Nrf2 activity and thus CBS expression