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An increased number of karyopyknotic cells was found in all four regions: cerebral and cerebellar cortex, hippocampus cortex, and hypothalamus/thalamus in control rats (Figure 8 and Figure 9)

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The preserved system facilitates repeated access when standard sterile procedures are followed and supports accurate reconstitution steps for lyophilized materials and calibration series in method development

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To assess the relation between AD biomarkers and TCD, we used a multivariate regression analysis, considering age, sex and vascular comorbidities as covariates