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Together, these might be the compelling evidence for the implemented concept of cytoprotection (i.e., the process by which chemical compounds provide protection to cells against harmful agents) [2,3,4,5,6,7,8]

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Early studies indicated that the 1 -ARs are more resistant to agonist-mediated downregulation compared with 2 -ARs, despite both receptors having similar rates of basal degradation (Liang et al., 2003

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