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Chemical and biological considerations in the treatment of metal intoxications by chelating agents

Pellegrini, L

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Upon recruitment to neoplastic sites or differentiation from resident populations within the tissue of origin, these macrophages undergo phenotypic reprogramming specific to the tumor microenvironment, resulting in discrete tumor-associated macrophage subpopulations

The resulting redox imbalance promotes oxidative damage to lipids (lipid peroxidation), proteins, and DNA, hallmarks of MNPs-induced cytotoxicity