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Wnt/-catenin pathway in bone disease Osteocytes play a central role in regulating bone metabolism and can regulate the balance of bone formation and bone resorption in bone modelling and remodelling through endocrine and autocrine methods
Between 70 to 88% of patients survive for 25 years following the onset of clinical symptoms, indicating a median time from symptom initiation to death ranging from 24 years to over 45 years

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CGRP and the nerve-bone connection Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide that has fundamentally changed how researchers understand the relationship between the nervous system and bone health
MMPs (such as MMP-1, -2, -3, -7, -9, -13, 14, and ADAMTS-4) are upregulated in IDD and correlate with the severity of degeneration (Huang YC