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Description
Mutations in the MBD4 gene heighten the risk and intricacy of various cancers by affecting DNA repair mechanisms, increasing mutational burden, and promoting the formation of specific mutational spectra

Barde S, et al

A clinical case covered in 2019 showed a 38-year-old female diagnosed with erythrodermic psoriasis also found some relief with LDN treatment when other medications had proven ineffective

However, pharmacological targeting of PTM-modifying enzymes often leads to pleiotropic effects, typically affecting the manifold substrates in addition to desired disease-driving pathways

TB still poses a significant public health challenge due to its high mortality and transmissibility
