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LASSO analysis penalizes proteins with only minor contributions in determining metabolite abundance by assigning a coefficient of zero, which nominates proteins that can be prioritized for biological validation

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Oxidative stress in erythrocytes During their life span, the erythrocytes are continuously exposed to high O 2 tension, due to their primary function as gas carriers, and are unable to synthesize new or repair damaged proteins, due to the lack of nucleus and other organelles