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Retrieved February 19, 2025

In a phase 3 Japanese trial, the pemafibrate group showed significantly reduced fasting TG levels by 45%, with significant decreases in non-HDL-C and increases in HDL-C levels [52]

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The authors speculate that an alteration in the nanostructure of the mRNA-LLPs may have caused the low in vivo efficacy, as such a change could affect properties like the binding to serum proteins, which are absent in the in vitro study

doi: 10.4103/2152-7806.85609 12 MurakamiTKiyosawaTMurataSUsuiKOhtsukiMNakagawaH