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Emerging clinical observations with smaller FGF21 analogs including pegbelfermin (50 kDa) and BIO89-100 (40 kDa), may provide insights into effects possibly mediated via the central nervous system

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George SM, Lu F, Rao M, Leach LL, Gross JM

176 While it remains debated whether neuroinflammation initiates or results from neurodegeneration, systemic inflammation is known to amplify CNS pathology

To test how the second effect changes the basis set, additional simulations were performed in VeSPA