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Additionally, pro-inflammatory factors such as CRP, IL-6 and IL-18, which are closely associated with the incidence of CVDs, are also elevated in the plasma of women with PCOS patients ( The critical role of macrophages in the pathogenesis of CVDs in PCOS has been recently reported, with a substantial augmentation in the number of M1-macrophages in the hearts of PCOS model mice, predominantly derived from circulating monocytes ( 2.3.2 Liver The prevalence of NAFLD is higher in PCOS patients than in healthy women (34%70% vs
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doi: 10.3389/fphar.2021.627533 Received 09 November 2020 Accepted 03 February 2021 Published 29 June 2021 Volume 12 - 2021 Edited by Gabor Varga, Semmelweis University, Hungary Reviewed by Alexandra Mik, University of Pcs, Hungary Zoltn S

Seghezza et al., 2014)

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