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Thus, it has been determined that increased intracellular calcium and calmodulin activation in the lens can activate connexin hemichannels (essential for mediating communication and the exchange of the molecules between cells, as well as between the intracellular and extracellular environments) in lens fibers, disrupting their proper homeostasis and consequently favoring cataract development [45]

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[PubMed] 191: Ng JS, Bearse MA Jr, Schneck ME, et al

5-Amino-1-methylquinolinium (5-Amino-1MQ) is a selective small molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme that plays a critical role in cellular metabolism and energy homeostasis