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Fensterseifer et al., 2015[36]

This coincided with an upregulation of the PI3K pathway, 61 and a 29 and 66% increase of Akt expression in MDA-MB-468 breast and SW480 colon cancer cell lines, respectively

For patients presenting between 4 and 8 hours post-ingestion, serum APAP levels should be measured and plotted on the Revised Rumack-Matthew nomogram to assess toxicity risk

Activation triggers the PI3K-Akt-mTOR and Ras-MAPK pathways, promoting protein synthesis, glucose uptake, and cell proliferation

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