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The amine and carboxylic acid groups of carnitine are the key groups for OCTN2 to recognize it, and the hydroxyl group of carnitine is esterified by acyl derivatives and does not hinder the recognition effect of OCTN2, indicating that OCTN2 has high substrate diversity and adaptability and is able to process a variety of acylcarnitines [162]

Protection of oligodendrocytes, myelin and neurons would be particularly important after neonatal or pediatric brain injury

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In vivo studies have shown that R162 prevents lung cancer metastasis in patient-derived xenograft models (Jin et al., 2018)

doi: 10.21037/atm.2019.11.53