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The primary functions of FC and acylcarnitines (AC), mainly acetyl-L-carnitine (ALC) in humans, are the transport of long-chain fatty acids (FAs) to the mitochondrial matrix and maintaining the mitochondrial homeostasis of coenzyme A (CoA) during mitochondrial oxidation of these acids [49]

doi: 10.1007/s11306-011-0343-y

Insufficient ATP production by the mitochondria and nutrient depletion activate the AMP-activated protein kinase (AMPK) [253], which initiates autophagy by phosphorylating and activating the components of the autophagy-activating protein complex and inhibiting the activity of mTORC1

These two fatty acids must be acquired from the diet and are, therefore, referred to as essential fatty acids