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J., Zimmer, A

Metformin attenuates hyperlipidemia/PA-induced vascular calcification through anti-ferroptosis effects (122)

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Collectively, these data indicate that the significantly reduced Aldh2 activity of Aldh2 KI mice results in elevated toxic aldehydes levels and, especially 4-HNE and increased 4-HNE adduction to proteins involved in mitochondrial reduced FAO and mitochondrial respiration of BAT, leading to markedly decreased FAO rate and mitochondrial respiration and subsequent reduced adaptive thermogenesis and energy expenditure