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Dihydroorotate dehydrogenase (DHODH) and G3P dehydrogenase 2 (GPD2) promote the conversion of mitochondrial membrane CoQ to CoQH 2 and thus protect mitochondrial membrane integrity [128, 129]

Through trans-signaling, IL-6 activates the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway, enhancing NF-B and leading to increased production of ROS and pro-inflammatory cytokines [29]

The treatment of rats with low concentrations of manuka honey did not produce a significant healing ability (Figures 1(d) and 1(e))

J Pharm Sci 105, 17791789

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