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Figure 3 Potential Therapeutic Measures of TMAO for AS Reduced Production of TMAO to Protect the Heart TMAO is an intestinal microbiota-dependent metabolite, which is accumulated in the body by ingestion of large amounts of substances rich in phosphatidylcholine

Studies have shown that L-carnitine supplementation can improve the health of the heart muscle, enhance exercise tolerance, and reduce symptoms of angina

Yohimbine is a selective alpha-2 adrenergic receptor antagonist (inactivator), which inhibits activation of the suppressive set of receptors and preserves Adenyl Cyclase activity and the effects mediated via the beta receptors

It should be noted that the cholesterol-binding activity of StAR is independent of its activity at the OMM, because StAR mutant R182L can still function in the binding and transfer of cholesterol in isolated liposomes, although this results in an increase in cholesterol present in the cell [71]

Carnitine and physical exercise