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The strongest human evidence is topical, including the Leyden 2002 photoaging trial and a 2023 IRB-approved 21-woman topical NEEL gel study reporting an average 28% increase in skin collagen density at 3 months

Emicizumab (FIXa FX) exemplifies this modality by mimicking coagulation factor VIII activity and facilitating factor X activation in patients with hemophilia A [242]

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