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Cellular studies have shown that exogenous NAD + can impact mitochondrial activity, such as boosting Krebs cycle and the ETC, but also impair genomic DNA replication and induce DNA replication stress due to impairment of pyrimidine biosynthesis 118
MartnezFernndez R., RodrguezRojas R., Del lamo M., et al

10.1007/s00701-003-0036-z 133 KavanaghR

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But the evidence these claims come from involves copper levels way higher than youd ever get from a serum
