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However, while the effect of IR on GPX4 activity may vary by cell type, it is well established that increased GSH and GPX4 levels are protective against IR-induced ferroptosis in both healthy and malignant cells [35, 51, 56, 57]

Overall, structural modifications, including the stapling motif ( i,i + 7), specific positioning of the staple, N- and C-terminal residues, conservation of leucine side chains, and preservation of charged/polar residues D146, E151, and N153 directed the improved potency and specificity of 1907 as a FAK scaffold inhibitor

For simplicitys sake, we refer to the GATA-binding motifs aligned in head-to-head and tail-to-tail palindromic orientations as Pal-GATA or rPal-GATA motifs, respectively

87 LallementP.-A.MeuxE.GualbertoJ

This plant has a potential market in both food and pharmaceutical industries, besides local uses 46 therefore, attracts the interest of local farmers for cultivating and harvesting it as a field crop