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doi: 10.1002/14651858.CD001289.pub2 23 Suarez-CuartinGHernandez-ArgudoMPereaLSibilaO

In contrast, cancer cells with high levels of SLC7A11 (SLC7A11 high ) have been observed to accumulate intracellular cystine when glucose levels are low, draining the cellular NADPH pool and leading to the aberrant accumulation of intracellular disulfides and subsequently to disulfidptosis, a previously uncharacterized form of cell death that differs from apoptosis and ferroptosis[89, 90]

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