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Levels of Nrf2 and -actin in cytosolic fractions as well as Nrf2 and lamin B1 in nuclear fractions of macrophages were measured using Western blot analysis

Notably, bile acid signaling pathways can also contribute to OA pathology, as indicated by the alleviation of murine OA after suppression of farnesoid X receptor-the receptor for the bile acid glycoursodeoxycholic acid (GUDCA), which upregulates intestinal glucagon-like peptide-1 secretion (Yang et al., 2025)

ACS Med Chem Lett

D., Parks J

Cellular triglyceride accumulation in the hepatocytes was inhibited by 10( E ),12( E )-9-oxo-ODE, a ketone produced from LA and isolated from tomato juice, via activation of PPAR in vitro